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Dulin, Nickolai
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overview Dr. Dulin’s laboratory investigates the signaling mechanisms of TGF-beta-induced myofibroblast differentiation as related to pathogenesis of pulmonary fibrosis, using cell culture and animal models of the disease. His studies have described the critical role for serum response factor (SRF) in myofibroblast differentiation and pulmonary fibrosis, as well as the control of this pathway by actin and microtubule dynamics. The other direction of Dr. Dulin research relates to the basic studies on the biological function of the regulators of G protein signaling (RGS) proteins, focusing on RGS3 member of the family. His group has shown that RGS3 regulates the signaling mediated by heterotrimeric Gi and Gq proteins, as well as non-canonically of TGF-beta signaling. Together with Dr. Anne Sperling, they established the role of RGS3 in control of T cell migration and T cell – mediated inflammation, using knock-down and knockout approaches. His current studies focus on the function of endogenous RGS3 as related to cancer cell growth, migration and EMT. Dr. Dulin's NIH Commons ID is NDULIN
One or more keywords matched the following items that are connected to Dulin, Nickolai
Item TypeName
Concept Collagen Type I
Concept Receptor, Fibroblast Growth Factor, Type 1
Concept Type C Phospholipases
Concept Calcium Channels, L-Type
Academic Article The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.
Academic Article Activation of cGMP-dependent protein kinase by protein kinase C.
Academic Article Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and L-type Ca2+ channels.
Academic Article Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)ß-mediated suppression.
Academic Article Angiotensin IV receptors and signaling in opossum kidney cells.
Academic Article Cation-chloride cotransporters: regulation, physiological significance, and role in pathogenesis of arterial hypertension.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.
Academic Article NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension.
Academic Article Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.
Academic Article Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFß.
Concept Cyclic GMP-Dependent Protein Kinase Type I
Grant Fibroblast Biology and Pulmonary Fibrosis
Grant Activation of protein kinase A by endothelin-1
Grant Control of myofibroblast activation and pulmonary fibrosis by Na/K-ATPase
Grant Novel functions of RGS3
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